Treponema
ORGANISM:
·
Familly :
Spirochaetaceae
·
Genus :Treponema
·
Spesies :Treponema
palidium
Treponema
pertenue
Treponema
carateum
GENERAL CONCEPTS:
- Three "treponematoses" are discussed:
syphilis, yaws and pinta.
- Each of these diseases is characterized by distinct
clinical stages. These stages are known as primary, secondary and
tertiary.
- The primary stage involves multiplication of the
bacteria at the site of entry to produce a localized infection.
- The secondary stage occurs following an asymptomatic
period and involves dissemination of the bacteria to other tissues.
- The tertiary stage may occur after 20-30 years.
- The Treponema are highly invasive organisms; T.
pallidum is the most invasive of the species, T. carateum the
least invasive.
DISTINCTIVE PROPERTIES:
- The Treponema are motile, helically coiled
organisms having a corkscrew-like shape. They stain very poorly because
their thickness approaches the resolution of the light microscope.
- Treponema
are delicate organisms requiring pH in the range 7.2 to 7.4, temperatures
in the range 30°C to 37°C and a microaerophilic environment.
- The structure of these organisms is somewhat different:
the cells have a coating of glycosamino-glycans, which may be
host-derived, and the outer membrane covers the three flagella that
provide motility.
- In addition, the cells have a high lipid content (cardiolipin,
cholesterol), which is unusual for most bacteria. Cardiolipin elicits
"Wassermann" antibodies that are diagnostic for syphilis.
- Treponema
possess a complex antigenic makeup that is difficult to determine because
the organisms cannot be grown in vitro.
PATHOGENESIS:
- Treponema pallidum
is capable of infecting all body tissues.
- The disease caused by T. pallidum is syphilis.
This is a relatively painless, slowly evolving disease. The host-parasite
relationship leads to short symptomatic periods when the organism
multiplies, followed by prolonged asymptomatic periods when host responses
produce healing.
- Syphilis is strictly a person-person disease.
- An incubation period of from 10 to 90 days precedes the
clinical presentation, despite the fact that the organisms disseminate
immediately. The prominent feature of the disease is vascular involvement,
particularly arterioles and capillaries.
- Treponemal antigen-host antibody complexes may cause
some immunosuppression of the host and production of the distinct clinical
stages:
- The primary stage occurs weeks to months following
infection. The principal sign of infection is the hard chancre, generally
found on the genitals. This lesion is essentially painless but filled
with treponemes and is, therefore, highly contagious.
- The secondary stage occurs following an asymptomatic
period of 2-24 weeks. In the secondary stage, a skin rash spreads from
the palms and soles towards the trunk. This rash may last 2-6 weeks and
is followed by recovery. On average, about 25% of patients experience
relapses of the secondary stage.
- Following the secondary stage is a period of latency
which may last many years and during which there are essentially no
clinical symptoms.
- The tertiary stage may erupt following the period of
latency and can affect all areas of the body and be fatal. Cardiovascular
and neurological involvement are the most frequent causes of death.
Typically, however, the appearance of lesions called "gummas"
mark the tertiary stage. These lesions are, in fact, large granulomas
resulting from hypersensitivity reactions and they can be extremely
disfiguring.
- Syphilis that occurs in utero is termed
congenital syphilis. About 50% of such fetuses abort or are stillborn. Of
those surviving birth, two scenarios are observed: the "early"
form shows symptoms that are apparent at birth; in the "late"
form, infants appear normal until they are about 2 years old and only then
display the traits known as "Hutchinson's triad", which include
interstitial keratitis, notched incisors and eighth nerve deafness.
- Other treponematoses include:
- Yaws: Caused by T. pertenue, this disease
occurs in tropical Africa, S. America, India, Indonesia and the Pacific
Isles (equitorial regions). Symptoms involve the occurrence of a painless
papule called the "Mother yaw" as the primary stage. Following
healing and complete dissemination of the organisms, many papules return
after 1-12 months and occur on the face and moist body areas.
- Pinta: Caused by T. carateum, this disease
occurs only in tropical Central and South America. It is characterized by
a painless papule (primary) followed 2-18 months later by secondary
papules on the hands, feet and scalp. These lesions heal slowly after
treatment (unlike syphilis, yaws).
HOST DEFENSES:- It is the intricate interplay between the organism and
the host immune system that defines the treponematoses.
- Immunity results in untreated persons but it is slow to
evolve.
- Immunity is probably a combination of both humoral and
cell-mediated defenses.
EPIDEMIOLOGY:
- Syphilis is found worldwide and is transmitted via
sexual contact (ages 20-24 are most affected).
- Because the route of transmission is the same, 10% of
gonorrhea patients also have syphilis.
- Yaws and pinta are not sexually transmitted and
generally affect children or adolescents. These diseases are often
geographically diagnosed.
DIAGNOSIS:
- Clinical:
The clinical manifestations of the treponematoses are generally
characteristic and readily identified.
- Laboratory:
Darkfield examination of material from a chancre can show the presence of
spirochetes. Immunological techniques including fluorescent treponemal
antibody (FTA) or T. pallidum immobilization (TPI) can be of great
assistance in observing the organisms. The Wassermann test looks for the
presence of antibody against cardiolipin. Many other tests are also
available.
CONTROL:
- Sanitary:
As with other sexually transmitted diseases (STDs), use of a condom helps
prevent infection.
- Immunological:
None are available.
- Chemotherapeutic: Benzathine penicillin (long acting) or penicillin G are the drugs of choice. One must be aware of a possible Jarisch-Herxheimer reaction following treatment of secondary or tertiary syphilis, however. The rapid release of treponemal antigens after lysis by penicillin can cause hypersensitivity reactions in some person.
